Vitamin C---whats reaches the blood system?

 

🧠 
Topic: Plasma Levels and Absorption Dynamics of Vitamin C

---

🔬 1. Plasma Levels via Oral Vitamin C Intake:

• A daily oral dose of 20 grams of vitamin C, when divided throughout the day, can raise plasma ascorbate levels to approximately 250 μmol/L.
  📚 (Hickey, Roberts, Miller, 2008)

🧴 2. Liposomal Vitamin C Absorption:

• Liposomal formulations significantly enhance bioavailability. A large single liposomal oral dose can achieve plasma free ascorbate concentrations of up to 400 μmol/L.
  📚 (Hickey, Roberts, Miller, 2008)

🛡️ 3. Retention at Low Intake:

• The human body tightly regulates and retains vitamin C at low intakes, maintaining plasma levels around 70 μmol/L with daily intake as low as 200 mg/day.
  📚 (Padayatty, Sun, Wang, et al. 2004)

💊 4. High-Dose Oral Dosing:

• A single oral dose of 5 grams can result in plasma levels near 250 μmol/L. Repeated doses throughout the day can sustain plasma levels above 400 μmol/L.
  📚 (Hickey, Roberts, Miller, 2008)

🦠 5. Illness-Induced Uptake Shift:

• During illness or physiological stress, the body's need for vitamin C increases. It dynamically uptakes more ascorbate from the gut to match tissue demand.
  📚 (Hickey, Roberts, Cathcart, 2005)

🚽 6. Bowel Tolerance Indicator:

• The bowel tolerance dose (the maximum oral dose without inducing diarrhea) increases with stress or illness. This metric reflects the body’s increased utilization during times of need.
  📚 (Cathcart, 2005)

---

🔗 Key Resources & Further Reading:

• Vitamin C and Cancer: Use of Oral Vitamin C
• The Real Story of Vitamin C and Cancer (PDF)
• The Trials and Tribulations of Vitamin C (PDF)
• Orthomolecular Medicine News Service

---