⚡️ 1. High-Carbohydrate Diet (90%+ CHO)
Main Pathway: Glycolysis
- Fuel Source: Glucose
- Storage Form: Glycogen (liver and muscle)
- Hormonal Shift:
- ↑ Insulin
- ↓ Glucagon
- ↓ Cortisol
- Energy Mode: Fast, anaerobic and aerobic
- Metabolic Traits:
- Low fat oxidation
- Minimal ketone production
- Elevated blood glucose turnover
- Hormone Parallel:
- Low FGF-21 activity (FGF21 suppressed in high glucose states)
- High insulin sensitivity initially, but risk of insulin resistance long-term if unchecked.
🧬 2. High-Protein Diet (Predominantly Protein)
Main Pathway: Gluconeogenesis (GNG)
- Fuel Source: Amino acids → Glucose
- Storage Form: Glucose (via hepatic conversion)
- Hormonal Shift:
- ↑ Glucagon
- Moderate ↑ Insulin
- ↑ Cortisol (if protein intake is extreme or carb-depleted)
- Energy Mode: Slower, protein-derived ATP production
- Metabolic Traits:
- GNG is slower than glycolysis
- Not optimal for fast performance
- Risk of ammonia build-up (urea cycle burden)
- Hormone Parallel:
- FGF21 moderately elevated, especially in carb-restricted, high-protein settings.
- Promotes energy expenditure and fat oxidation supportively.
🔥 3. High-Fat Diet (Predominantly Fat – Keto/Carnivore)
Main Pathway: Ketosis
- Fuel Source: Fatty acids → Ketone bodies (β-HB, acetoacetate)
- Storage Form: Triglycerides
- Hormonal Shift:
- ↓ Insulin
- ↑ Glucagon
- ↑ FGF21 —> Key ketogenic adaptation hormone
- ↑ Adiponectin
- Energy Mode: Sustained, clean-burning, mitochondrial-efficient
- Metabolic Traits:
- Appetite suppression
- Muscle preservation (especially in presence of ketones)
- Cognitive stability and endurance
- Hormone Parallel:
- High FGF21 levels, which promotes fat oxidation, mitochondrial biogenesis, and insulin sensitivity.
- FGF21 is a hallmark of fasting and ketogenic states, acting like a master switch for adaptive metabolism.
⚙️ Summary Comparison Table:
Macronutrient Focus | Metabolic Pathway | Primary Hormone(s) | FGF21 Response | Energy Mode |
---|---|---|---|---|
High-Carb (90% CHO) | Glycolysis | ↑ Insulin | ↓ FGF21 | Fast, glycolytic |
High-Protein | Gluconeogenesis (GNG) | ↑ Glucagon, Cortisol | ↑ FGF21 (mod) | Moderate, stress-adapted |
High-Fat (Keto) | Ketosis | ↑ FGF21, Glucagon | ↑↑ FGF21 | Efficient, endurance |
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