Cortisol's Role in Vitamin C Uptake: Cortisol significantly enhances the uptake of vitamin C into cells by stimulating the production of messenger RNA

 

Cortisol's Role in Vitamin C Uptake: Cortisol significantly enhances the uptake of vitamin C into cells by stimulating the production of messenger RNA, which increases the expression of sodium-ascorbate co-transporters (SVCTs) (Fujita et al., 2001; Mikirova et al., 2019).

    Gluconeogenesis and Cortisol: Cortisol, a glucocorticoid hormone, increases glucose levels in the blood through gluconeogenesis in the liver, which utilizes amino acids and other non-carbohydrate molecules to produce more glucose (Cryer, 1993).

    Synergistic Effect: The synergistic relationship between cortisol and vitamin C suggests that when cortisol is released, it enhances the cellular uptake of vitamin C, which is crucial for resolving oxidative stress and inflammation (Savini et al., 2008).

Key Information

    Cortisol and Vitamin C Synergy: Cortisol enhances vitamin C uptake by stimulating the production of messenger RNA needed for sodium-ascorbate co-transporters, which are crucial for cellular vitamin C uptake (Fujita et al., 2001; Mikirova et al., 2019).

    Gluconeogenesis Role: Cortisol induces gluconeogenesis, increasing blood glucose levels, which indirectly supports vitamin C synthesis and uptake in the body (Cryer, 1993).

    Clinical Implications: Simultaneous administration of cortisol and vitamin C can enhance their respective impacts, particularly in conditions of oxidative stress and inflammation (Savini et al., 2008).

Data Related to the Problem

    Cortisol and Vitamin C: Cortisol facilitates vitamin C entry into cells, enhancing the Fenton reaction, which is crucial for pathogen destruction during infections (Levy, 2021).

    Vitamin C and Cortisol in Sepsis: High doses of vitamin C, along with cortisol, have been shown to significantly reduce mortality in septic patients by decreasing oxidative stress (Marik et al., 2017).

Sources

    Orthomolecular Medicine News Service: "Vitamin C and Cortisol: Synergistic Infection and Toxin Defense" by Thomas E. Levy, MD, JD. Available at Orthomolecular Medicine News Service.

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